Reserveage :: FAQs

FAQs

What is resveratrol?

Resveratrol—a molecular compound found in grapes, peanuts, Japanese knotweed and some berries—enables these plants to thrive in adverse growing conditions. Creating a powerful barrier against a variety of harmful stressors, Resveratrol helps plants survive injury, infectious pathogens, bacteria, fungi, and ultra-violet radiation. The humidity and warm climate typical of grape growing regions leave young plants susceptible to harmful mold and mildew, thus creating the ideal growing conditions for high Resveratrol production.

In the grape plant, the skins yield the highest concentration of Resveratrol. Since the skins are essential in the production of red wine, red wine itself contains varying levels of the rejuvenating molecular compound.

 What is trans-resveratrol?

The secret to anti-aging lies with trans-Resveratrol, the active form of Resveratrol polyphenols found in the skins, seeds and stems of red wine grapes. Trans-Resveratrol remains active only when protected from exposure to sun, light and oxygen. In this pure, ultra-beneficial form, trans-Resveratrol has been proven in studies to activate the SIRT1 longevity gene and enhance cellular productivity. Trans-Resveratrol is found here and available to you at its peak of potency.

Several research studies have shown that trans-Resveratrol significantly modulates biomarkers of bone metabolism, inhibits pro-inflammatory enzymes such as COX-1 and COX-2, and exhibits chemopreventive agents, anticarcinogenic properties, cardioprotective effects, neuroprotective properties, and caloric restrictive behavior.

The key to cellular energy lies within the mitochondria, which has been proven to be the foundation of living longer. Trans-Resveratrol has been shown to increase the number of mitochondria, thereby boosting your total daily energy, improving aerobic capacity, and enhancing sensorimotor function.

What are the potential advantages of taking resveratrol?

Healthcare professionals were baffled by the French Paradox—the lower occurrence of heart disease among the people in France despite a high-fat diet and a lifestyle virtually devoid of exercise. The French suffer significantly less coronary problems than Americans who consume a low-fat diet and exercise regularly. Upon closer analysis of the Paradox, medical and health professionals concluded that daily consumption of red wine contributed greatly to the healthy hearts of France. Further studies led to the discovery of the key ingredient—one of the most potent antioxidants ever found—RESVERATROL.

Studies show that Resveratrol, a natural life extender, has beneficial effects on a number of aliments associated with aging. According to scientific research, Resveratrol activates the SIRT1 gene, which biologists believe play's a fundamental role in regulating the lifespan of mammals. Activating this gene supports and improves mitochondria, which generates energy in our body’s cells. Scientists have found that increasing the activity of SIRT1 gene extends one’s life by slowing, postponing or eliminating diseases of old age.

Resveratrol’s ability to chelate, that is to remove plaque formations from the brain, has lead to studies exploring its healing properties in regards to the human brain. Scientific researchers have theorized that Resveratrol, taken on a daily basis, may significantly reduce neurodegenerative diseases commonly associated with aging.

Resveratrol supports cellular health in numerous ways. A powerful antioxidant, full-spectrum trans- Resveratrol boosts and invigorates cellular energy, lowering cholesterol while raising levels of the protective HDL. Helping to maintain the delicate balance of the immune system, the molecule compound targets harmful free radicals, neutralizing them, thereby protecting and prolonging the effects of healthy cell renewal.

I heard resveratrol increases endurance. Is this true?

According to a study conducted by the Institute of Genetics, Molecular and Cellular Biology, participants given oral doses of Resveratrol were able to run 100% farther than participants not given the Resveratrol. The Resveratrol-dosed participants also displayed a reduced heart rate and less energy-charged muscle mass—physical characteristics associated with highly trained athletes. According to the study's leading scientist, Johan Auwerx, “Resveratrol makes you look like a trained athlete without the training.” Furthermore, Mr. Auwerx, based on his analysis of the gene influenced by Resveratrol and a study conducted in Finland, expects the same response to occur in humans.

What is the cause of this increase in endurance?

Resveratrol significantly increases and strengthens the number of mitochondria found in the muscle cells of participants. Mitochondria are responsible for generating cellular energy; this increase in mitochondria doubled the participants’ endurance. According to Mr. Auwerx, Resveratrol alters muscle fibers to make them more like the muscle fibers of a trained athlete.

Will resveratrol help me to lose weight?

A November, 2007 study, published in the journal Cell, revealed that the Resveratrol-strengthened mitochondria not only doubled the participants’ endurance, but it also increased their metabolic rate. In essence, the participants were now able to burn significantly more calories, thereby avoiding weight gain. According to Johan Auwerx, a leading researcher of the study, other recent clinical trials of both men and women indicate that Resveratrol will likely produce similar results in humans. The participants also did not experience decreased sensitivity to insulin (a symptom of being overweight and a cause of diabetes).

At what point during the day should I take Resveratrol?

Resveratrol can be taken at any time during the day.

Should I take Resveratrol on an empty stomach?

Resveratrol can be taken on an empty or full stomach, as it absorbs equally well either way. However, like many supplements, people with sensitive stomachs may find they prefer to take Resveratrol with a full stomach.

Do your supplements contain alcohol?

No. The Resveratrol in our products is extracted from the grapes long before the fermentation process begins.

Are all of your products vegetarian?

All of our products, with the exception of the Collagen Booster, are manufactured in veggie capsules and are vegan and vegetarian friendly.

Can I take Resveratrol in conjunction with other medications?

Resveratrol is safe to be taken with all medications except some prescription blood thinners. If you are on a prescription blood thinner, please consult with your doctor before trying Resveratrol.

Can I take Resveratrol with other supplements?

Yes! Resveratrol is safe to be taken with other supplements.

Can I take more than one of your product at a time? Can I mix your different products?

Yes, all of our products can be mixed. In fact many of our customers take a dose of Resveratrol in combination with one of our other products. Just keep an eye on how much trans-Resveratrol you are taking, as we do not recommend dosages over 5,000 MG per day.

Is it normal for your products to emit a distinct, earthy scent?

Since we prefer to use organic and natural ingredients, it is common for some of our products to have a vividly natural odor and color.

I have type 2 diabetes. Is it safe to take resveratrol?

Scientists and medical professionals expect that Resveratrol will be a breakthrough treatment for type 2 diabetes!

In January of 2008 Sirtris Pharmaceuticals announced that its version of Resveratrol “significantly” lowered glucose, administered by an oral glucose tolerance test, in humans with type 2 diabetes. Doses of 2.5 or 5 grams were administered orally once a day for 28 days. The patients experienced “no serious adverse events and no dose-related adverse events.” In other words, Resveratrol helped lower glucose in diabetic patients without causing damaging side effects.

Furthermore, an October study indicated the possibility of even smaller doses, the equivalent of 15 mg. of Resveratrol, having the same beneficial effects by increasing insulin sensitivity in diabetic participants.

In July 2007, Sirtris Pharmaceuticals announced that its version of Resveratrol reduced glucose and improved insulin sensitivity in multiple pre-clinical models of type 2 diabetes. A November 2007 study released in the journal Cell indicated that Resveratrol, administered orally to participants, protected them from gaining weight and developing diabetes. Lead researcher Johan Auwerx explained that, based on the findings of a Finnish study, Resveratrol would likely produce similar results in humans.

It is possible that Resveratrol fights diabetes in two ways: first, by reducing glucose and improving insulin sensitivity and, second, by increasing the metabolic rates of animals, thereby decreasing weight gain—a main contributor of type 2 diabetes.

I’ve heard resveratrol is good for the heart. Can you please explain why?

Several studies indicate that consuming resveratrol may help protect the human heart. There are several reasons why this may be true:
  • Inflammation is the body’s natural response and process to injuries caused or exacerbated by bacterial infections or viruses. According to numerous studies, inflammation is a contributing factor in fatty deposits building up in the lining of arteries (also known as atherosclerosis). These fatty deposits can then clog arteries and cause heart attacks or strokes. Likewise, blood clots, formed by blood platelets, can partially or fully block coronary or cerebral arteries, also causing heart attacks or strokes. Scientific research and laboratory studies have found that Resveratrol inhibits both the blood platelets from aggregating and the activity of several inflammatory enzymes (in vitro). In other words, Resveratrol helps keep your arteries clear, helping to prevent heart attacks and strokes.
  • Many researchers believe that Resveratrol is at least partially responsible for the cholesterol-lowering, both total cholesterol and LDL cholesterol, effects of red wine. Resveratrol is believed to block cholesterol oxidation because of its powerful antioxidant properties.
  • 5 to 10% of heart attack victims continue to suffer from a condition called arterial fibrillation, which is when the top chambers of the heart flutter. This condition can produce blood clots that may then result in a stroke. In a recent study, Resveratrol was given to a selected group of participants before a heart attack was induced; another group of participants received nothing. The mortality rate of participants who received the Resveratrol was just 10% and fibrillation lasted an average of 112 seconds. Fairing much worse, the participants who received no Resveratrol had a 50% mortality rate and fibrillation lasting an average of 164 seconds.

Does resveratrol help prevent cancer?

Resveratrol has been proven to fight cancer, in vitro, at all three stages;
  • Initiation
  • Promotion
  • Progression
Resveratrol is a powerful antioxidant that can help prevent cell damage caused by free radicals. Damaged cells are more likely to become cancerous than healthy cells.

Resveratrol has been proven to induce cancer cells to die like healthy cells, which die in their natural life cycle. Typical cancer treatments, such as radiation and chemotherapy, instead cause cancer cells to break open and release their contents into the body, creating inflammation in neighboring cells. Resveratrol, on the other hand, induces the white blood cells to consume the cellular debris of the dead cancer cell, a process called apoptosis.

What about skin cancer?

Several studies have shown that Resveratrol applied to the skin of hairless participants before exposure to solar (UVB) radiation helped to prevent skin tumors. Interestingly, Resveratrol applied to the skin of hairless participants after exposure to solar (UVB) radiation produced the same results. Perhaps one day Resveratrol will be used both prevent and/or treat skin cancer!

Does resveratrol have any effect on Alzheimer’s disease?

Recent studies suggest that Resveratrol might be helpful in preventing and/or ameliorating Alzheimer’s disease. One of the characteristics of Alzheimer’s disease is the deposition of plaques in the brain. These plaques are caused by amyloid-beta peptides. Recent scientific studies suggest that introducing and adding Resveratrol to the cells that create the amyloid-beta peptides significantly reduces the cellular levels of these destructive plaques in the brain.

Are you suggesting that resveratrol, taken orally, may effectively treat the brain?

Science has not conclusively answered this question. However, one recent study did conclude that Resveratrol has the ability to pass through the blood-brain barrier. The blood-brain barrier is a blood vessel wall which prevents toxins and other compounds, both good and bad, from entering the brain. Regardless of this barrier, Resveratrol has the ability to penetrate it and effectively reach, and perhaps, treat the brain.

Source: Resveratrol Co.

What conditions or problems is resveratrol used for?

Resveratrol helps lower cholesterol and is as much as 10 to 20 times more potent than vitamin E in protecting against LDL oxidation, a process that has been linked to the development of cardiovascular disease. Resveratrol may also discourage tumor growth by blocking the action of Cox-2, an enzyme that researchers believe contributes to the development of colon cancer. Research has also focused on Resveratrol’s ability to selectively target, kill and stop cancer cells from spreading to the three steps of cancer progression: 1) initiation, 2) promotion and 3) progression. The potential of Resveratrol having positive effects on inhibiting cancer is impressive. The list of cancerous tumors that Resveratrol may inhibit is astonishing: prostate cancer, breast cancer, melanoma, liver cancer, brain cancer, pancreatic cancer, kidney cancer, colon cancer, ovarian and cervical cancer, and lymphoma. It even appears to act as an anti-leukemia agent.

How much resveratrol is enough? How much is too much?

Since researchers are just beginning to explore the possible benefits of Resveratrol, no Recommended Dietary Allowance (RDA) or tolerable upper limit has been set for this substance, although the usual dose for Resveratrol is about 250 milligrams per day. It is advised that customers take no more than 5,000 milligrams per day.

Are there risks associated with using resveratrol?

No, as of today, no toxic reactions or effects have been associated with the consumption of Resveratrol regardless of the dosage. However, as Resveratrol increases blood flow and circulation throughout the body, it could, theoretically, increase the effect of prescription blood thinners. For this reason, individuals using such medications may wish to consult a physician before supplementing with Resveratrol. Resveratrol should not be taken by pregnant women or children, as its safety has not yet been established for these groups.

Can you get enough resveratrol from dietary/food sources?

The best dietary sources of Resveratrol are red grapes, wine, peanuts, and berries such as mulberries. In order to achieve the optimum Resveratrol needed for maximum health benefits you would need to consume a vast and almost impossible amount of these foods on a daily basis. For this reason Resveratrol supplements may be a more reliable and concentrated source of this valuable nutrient especially for those that don’t regularly consume red wine or grape juice, and/or are concerned about their calorie, carbohydrate, or sugar intake.

Source: Vitamin Stuff

Resveratrol is also found in Polygonum cuspidatum, also known as Japanese Knotweed. In Asia, Japanese Knotweed has long been known for its health benefits and has been used for centuries to treat both heart and liver disorders. Most Resveratrol supplements available in stores today are formulated with a blend of Polygonum cuspidatum root powder, grape extracts and other antioxidants.

Is resveratrol safe?

Resveratrol has been approved by EPA as non-toxic. It has passed the safety-arm of three human clinical trials. It has also been shown to be non-toxic in animal tests (21,000 mg human equivalent). Resveratrol has been reviewed for toxicity by the National Institute of Environmental Health Sciences.

Source: Resmedin

Does resveratrol extend life in certain organisms?

Resveratrol has been shown to activate the SIRT1 gene, which is believed by biologists to have a fundamental role in effecting longevity. It plays a major role in supporting and strengthening mitochondrial function. In a widely asserted theory, it is thought that Resveratrol also activates the Sirtuins / SIR2 enzyme, found in many living organisms. It is believed that the SIR2 extends cell life by ‘coercing’ them to repair their DNA as well as increase their production of protective and beneficial antioxidants. Researchers believe Resveratrol extends the life of individual cells as well as the lives of ‘host’ organisms. Interestingly, prior to the Resveratrol discovery, researchers thought the SIR2 enzyme could only be activated by severe calorie reduction, 40% of a normal diet. Science has already proven the significant health and longevity benefits of a severely restricted caloric diet for participants and observations of monkeys and humans leaves many in the scientific community optimistic. Resveratrol has been found to have the same benefits without the hardships imposed by such a severe dietary undertaking.

Many scientists, and those in the venture capital community, are extremely optimistic about the future of Resveratrol for disease prevention, disease treatment, and life extension. Researchers from institutions such as Harvard and the Massachusetts Institute of Technology (MIT) are currently developing pharmaceuticals based on the chemical structure and properties of Resveratrol. It is believed that these drugs are five or more years away from commercial and regulatory feasibility.